abstract：:Previous research has shown that healthy individuals who fail to differentiate among emotional states (i.e., those with low emotional granularity; EG) have poorer social functioning (SF) than those with high EG. It is unknown, however, whether these associations extend to clinical disorders characterized by impaired S...

journal_title：Journal of psychiatric research

authors： Kimhy D,Vakhrusheva J,Khan S,Chang RW,Hansen MC,Ballon JS,Malaspina D,Gross JJ

更新日期：2014-06-01 00:00:00

abstract：:Exposure to early life stress (ELS) is strongly associated with poor treatment outcomes, particularly for trauma-associated disorders such as depression. Little research to date, however, has examined the potential effects of ELS on outcomes with newer treatments, such as repetitive transcranial magnetic stimulation (...

journal_title：Journal of psychiatric research

authors： Philip NS,Valentine TR,Sweet LH,Tyrka AR,Price LH,Carpenter LL

更新日期：2014-05-01 00:00:00

abstract：:Adults with schizophrenia present cognitive impairments, as do individuals at ultra-high risk for the disorder, youth with relatives with schizophrenia spectrum disorders, and children with antecedents of schizophrenia. The present study aimed to determine if impairments in childhood differed depending on the definiti...

journal_title：Journal of psychiatric research

authors： Dickson H,Cullen AE,Reichenberg A,Hodgins S,Campbell DD,Morris RG,Laurens KR

更新日期：2014-03-01 00:00:00

abstract：:Attention-deficit and hyperactivity disorder (ADHD) is a common psychiatric disorder with a worldwide prevalence of 5-6% in children and 4.4% in adults. Recently, copy number variations (CNVs) have been implicated in different neurodevelopmental disorders such as ADHD. Based on these previous reports that focused on p...

journal_title：Journal of psychiatric research

authors： Ramos-Quiroga JA,Sánchez-Mora C,Casas M,Garcia-Martínez I,Bosch R,Nogueira M,Corrales M,Palomar G,Vidal R,Coll-Tané M,Bayés M,Cormand B,Ribasés M

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Repeated exposure to the traumatic memory (RETM) is a common component of treatments for posttraumatic stress disorder (PTSD). This treatment is based on a fear extinction model; however, the degree to which this treatment actually engages and modifies neural networks mediating fear extinction is unknown. Th...

journal_title：Journal of psychiatric research

authors： Cisler JM,Steele JS,Lenow JK,Smitherman S,Everett B,Messias E,Kilts CD

更新日期：2014-01-01 00:00:00

abstract：:Early responses to stimuli can be measured by sensory evoked potentials (EP) using repeated identical stimuli, S1 and S2. Response to S1 may represent efficient stimulus detection, while suppression of response to S2 may represent inhibition. Early responses to stimuli may be related to impulsivity. We compared EP ref...

journal_title：Journal of psychiatric research

authors： Swann AC,Lijffijt M,Lane SD,Steinberg JL,Acas MD,Cox B,Moeller FG

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVES:Impaired response inhibition underlies symptoms and altered functioning in patients with bipolar disorders (BD). The interpretation of fMRI studies requires an accurate estimation of neurocognitive performance, for which individual studies are typically underpowered. Thus, we performed the first combined met...

journal_title：Journal of psychiatric research

authors： Hajek T,Alda M,Hajek E,Ivanoff J

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Motivational impairments are a core feature of schizophrenia and although there are numerous reports studying this feature using clinical rating scales, objective behavioural assessments are lacking. Here, we use a translational paradigm to measure incentive motivation in individuals with schizophrenia. MET...

journal_title：Journal of psychiatric research

authors： Fervaha G,Graff-Guerrero A,Zakzanis KK,Foussias G,Agid O,Remington G

更新日期：2013-11-01 00:00:00

abstract：:Executive dysfunction is a core deficit in schizophrenia (SCH). However, some controversy exists when examining such deficits in studies of bipolar disorder (BD). The aim of the present research was to investigate whether executive deficits were similar or distinct in both illnesses. 148 patients with BD, 262 patients...

journal_title：Journal of psychiatric research

authors： Ancín I,Cabranes JA,Santos JL,Sánchez-Morla E,Barabash A

更新日期：2013-11-01 00:00:00

abstract：:Gender Identity Disorder (GID) is characterized by a strong and persistent cross-gender identification that affects different aspects of behavior. Brain-derived neurotrophic factor (BDNF) plays a critical role in neurodevelopment and neuroplasticity. Altered BDNF-signaling is thought to contribute to the pathogenesis ...

journal_title：Journal of psychiatric research

authors： Fontanari AM,Andreazza T,Costa ÂB,Salvador J,Koff WJ,Aguiar B,Ferrari P,Massuda R,Pedrini M,Silveira E,Belmonte-de-Abreu PS,Gama CS,Kauer-Sant'Anna M,Kapczinski F,Lobato MI

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Although schizophrenia and major depressive disorder (MDD) differ on a variety of neuroanatomical measures, a diagnostic tool to discriminate these disorders has not yet been established. We tried to identify structural changes of the brain that best discriminate between schizophrenia and MDD on the basis of...

journal_title：Journal of psychiatric research

authors： Ota M,Ishikawa M,Sato N,Hori H,Sasayama D,Hattori K,Teraishi T,Noda T,Obu S,Nakata Y,Higuchi T,Kunugi H

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Quality of life (QOL) is now recognised as an important measure of outcome that could potentially influence clinical decision-making for those with a first-episode psychosis (FEP). A number of QOL instruments are available however; many differ in their conceptual orientation which may have serious implicatio...

journal_title：Journal of psychiatric research

authors： Renwick L,Lyne J,Owens E,O' Donoghue B,Madigan K,Turner N,Drennan J,Sheridan A,Kinsella A,Clarke M,O' Callaghan E

更新日期：2013-10-01 00:00:00

abstract：:Many psychiatric patients have a minor blood-CSF barrier dysfunction and increased Cerebrospinal fluid (CSF) neopterin concentrations. The source of normal CSF neopterin, a biomarker in inflammatory and non-inflammatory neurological diseases, has never been shown explicitly, a precondition for sensitive detection of p...

journal_title：Journal of psychiatric research

authors： Kuehne LK,Reiber H,Bechter K,Hagberg L,Fuchs D

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVE:To investigate possible differences in peripheral levels of chemokines, BDNF and oxidative markers between patients with Schizophrenia (SZ) and matched healthy controls, and investigate the correlation of these biomarkers with cognitive performance. METHODS:Thirty individuals with SZ and 27 healthy controls ...

journal_title：Journal of psychiatric research

authors： Asevedo E,Gadelha A,Noto C,Mansur RB,Zugman A,Belangero SI,Berberian AA,Scarpato BS,Leclerc E,Teixeira AL,Gama CS,Bressan RA,Brietzke E

更新日期：2013-10-01 00:00:00

abstract：:Reports have described how psychiatric patients respond to disasters. However, previous reports on the response depending on diagnostic categories have provided no clear consensus. Here we analyzed response to the Great East Japan Earthquake of March 11, 2011, among psychiatric patients in light of severity of pre-exi...

journal_title：Journal of psychiatric research

authors： Funayama M,Mizushima J

更新日期：2013-10-01 00:00:00

abstract：:CNTNAP2 is a gene on chromosome 7 that has shown associations with autism and schizophrenia, and there is evidence that it plays an important role for neuronal synchronization and brain connectivity. In this study, we assessed the relationship between Diffusion Tensor Imaging (DTI), a putative marker of anatomical bra...

journal_title：Journal of psychiatric research

authors： Clemm von Hohenberg C,Wigand MC,Kubicki M,Leicht G,Giegling I,Karch S,Hartmann AM,Konte B,Friedl M,Ballinger T,Eckbo R,Bouix S,Jäger L,Shenton ME,Rujescu D,Mulert C

更新日期：2013-10-01 00:00:00

abstract：:Current evidences support inflammation, oxidative and nitrogen stress, as well as brain-derived neurotrophic factor (BDNF) signaling mechanisms as important in depression pathophysiology. Tetracycline antibiotics have anti-inflammatory and antioxidant properties. Preliminary evidence indicates that minocycline has ant...

journal_title：Journal of psychiatric research

authors： Mello BS,Monte AS,McIntyre RS,Soczynska JK,Custódio CS,Cordeiro RC,Chaves JH,Vasconcelos SM,Nobre HV Jr,Florenço de Sousa FC,Hyphantis TN,Carvalho AF,Macêdo DS

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Bipolar disorder may be associated with peripheral immune system dysfunction; however, results in individual studies are conflicting. Our aim was to systematically review evidence of peripheral cytokine alterations in bipolar disorder integrating findings from various affective states. METHODS:We conducted ...

journal_title：Journal of psychiatric research

authors： Munkholm K,Braüner JV,Kessing LV,Vinberg M

更新日期：2013-09-01 00:00:00

abstract：:Women with postnatal depression (PND) appear to have abnormal hypothalamic pituitary adrenal (HPA) axis responses to stress, which might involve a genetic variability component. We investigated association of genetic variants in the glucocorticoid receptor (GR, NR3C1) and corticotropin releasing hormone receptor 1 (CR...

journal_title：Journal of psychiatric research

authors： Engineer N,Darwin L,Nishigandh D,Ngianga-Bakwin K,Smith SC,Grammatopoulos DK

更新日期：2013-09-01 00:00:00

abstract：:Glutamatergic therapies are emerging as the new path for the treatment of Major Depression Disorder. Recent reports reviewing the use of glutamate activity modulators in the treatment of resistant depression advocate the importance of understanding the alterations of the diverse components of this complex system in mo...

journal_title：Journal of psychiatric research

authors： Medina A,Burke S,Thompson RC,Bunney W Jr,Myers RM,Schatzberg A,Akil H,Watson SJ

更新日期：2013-09-01 00:00:00

abstract：:This study aimed to explore the associations between daily cannabis use and the specific profiles of subclinical symptoms in a non-clinical population obtained through snowball sampling, taking into account alcohol use, other drug use, social exclusion and age at onset of cannabis use. We included 85 daily cannabis us...

journal_title：Journal of psychiatric research

authors： Ruiz-Veguilla M,Barrigón ML,Hernández L,Rubio JL,Gurpegui M,Sarramea F,Cervilla J,Gutiérrez B,James A,Ferrin M

更新日期：2013-08-01 00:00:00

abstract：:Negative symptoms are the most resilient manifestations in schizophrenia. An imbalance in dopamine and glutamate pathways has been proposed for the emergence of these symptoms. SP1, SP3 and SP4 transcription factors regulate genes in these pathways, suggesting a possible involvement in negative symptoms. In this study...

journal_title：Journal of psychiatric research

authors： Pinacho R,Villalmanzo N,Roca M,Iniesta R,Monje A,Haro JM,Meana JJ,Ferrer I,Gill G,Ramos B

更新日期：2013-07-01 00:00:00

abstract：:Bipolar disorder (BD) and nicotine dependence (ND) often co-occur. However, the mechanisms underlying this association remain unclear. We aimed to examine, for the first time in a national and representative sample, the magnitude and direction of the temporal relationship between BD and ND; and to compare, among indiv...

journal_title：Journal of psychiatric research

authors： Martínez-Ortega JM,Goldstein BI,Gutiérrez-Rojas L,Sala R,Wang S,Blanco C

更新日期：2013-07-01 00:00:00

abstract：:We compared scores from three different ratings methods in a clinical trial of patients with Major Depressive Disorder (MDD). The Quick Inventory of Depressive Symptoms (QIDS-SR16) was compared to site-based clinician and centralized (site-independent) ratings of the Inventory of Depressive Symptoms (IDSc30). An extra...

journal_title：Journal of psychiatric research

authors： Targum SD,Wedel PC,Robinson J,Daniel DG,Busner J,Bleicher LS,Rauh P,Barlow C

更新日期：2013-07-01 00:00:00

abstract：:Several lines of evidence, including psychopathological, neurobiological, pharmacological and epidemiological data, supported the association between Anorexia Nervosa (AN) and Obsessive-Compulsive Disorder (OCD). The aim of the present study is to test the hypothesis of partial common genetic background of both diseas...

journal_title：Journal of psychiatric research

authors： Mas S,Plana MT,Castro-Fornieles J,Gassó P,Lafuente A,Moreno E,Martinez E,Milà M,Lazaro L

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Previous studies indicate that negative symptoms reflect a separable domain of pathology from other symptoms of schizophrenia. However, it is currently unclear whether negative symptoms themselves are multi-faceted, and whether sub-groups of patients who display unique negative symptom profiles can be identi...

journal_title：Journal of psychiatric research

authors： Strauss GP,Horan WP,Kirkpatrick B,Fischer BA,Keller WR,Miski P,Buchanan RW,Green MF,Carpenter WT Jr

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Disturbances in prefrontal cortex phospholipid and fatty acid composition have been reported in patients with schizophrenia (SCZ), often as an incomplete lipid profile or a percent of total lipid concentration. In this study, we quantified absolute concentrations (nmol/g wet weight) and fractional concentrat...

journal_title：Journal of psychiatric research

authors： Taha AY,Cheon Y,Ma K,Rapoport SI,Rao JS

更新日期：2013-05-01 00:00:00

abstract：:The neurophysiological bases of cognitive-behavioral therapy (CBT) for obsessive-compulsive disorder (OCD) are incompletely understood. Previous studies, though sparse, implicate metabolic changes in pregenual anterior cingulate cortex (pACC) and anterior middle cingulate cortex (aMCC) as neural correlates of response...

journal_title：Journal of psychiatric research

authors： O'Neill J,Gorbis E,Feusner JD,Yip JC,Chang S,Maidment KM,Levitt JG,Salamon N,Ringman JM,Saxena S

更新日期：2013-04-01 00:00:00

abstract：:Subjective quality of life (QOL) has been recognized as an important consideration in schizophrenia. Several symptoms and neurocognitive functions were shown to be correlated with subjective QOL; however its determinants are not well understood. In this study, we investigated the association between brain structural a...

journal_title：Journal of psychiatric research

authors： Ubukata S,Miyata J,Yoshizumi M,Uwatoko T,Hirao K,Fujiwara H,Kawada R,Fujimoto S,Tanaka Y,Kubota M,Sasamoto A,Sawamoto N,Fukuyama H,Takahashi H,Murai T

更新日期：2013-04-01 00:00:00

abstract：:The investigation of neural substrates of autism spectrum disorder using neuroimaging has been the focus of recent literature. In addition, machine-learning approaches have also been used to extract relevant information from neuroimaging data. There are only few studies directly exploring the inter-regional structural...

journal_title：Journal of psychiatric research

authors： Sato JR,Hoexter MQ,Oliveira PP Jr,Brammer MJ,MRC AIMS Consortium.,Murphy D,Ecker C

更新日期：2013-04-01 00:00:00

abstract：:Neuroimaging studies in multiple modalities have implicated the left or right dorsolateral prefrontal cortex (here, middle frontal gyrus) in attentional functions, in ADHD, and in dopamine agonist treatment of ADHD. The far lateral location of this cortex in the brain, however, has made it difficult to study with magn...

journal_title：Journal of psychiatric research

authors： Tafazoli S,O'Neill J,Bejjani A,Ly R,Salamon N,McCracken JT,Alger JR,Levitt JG

更新日期：2013-04-01 00:00:00

abstract：INTRODUCTION:Doublecortin (DCX) and polysialilated neural cell adhesion molecule (PSA-NCAM), two proteins associated with immature neuronal phenotypes and elevated neuroplasticity in the adult brain, have recently been identified in the mammalian amygdala, and evidence from rodent studies suggests that stress may modif...

journal_title：Journal of psychiatric research

authors： Maheu ME,Davoli MA,Turecki G,Mechawar N

更新日期：2013-03-01 00:00:00

abstract：:Cholesterol (CHL) and phospholipid (PL) levels in synaptosomal membranes in particular can have an impact on cell signalling. Alterations in peripheral CHL measures have been consistently reported in suicidal behaviour. As CHL and PL turnover in the brain are important in synapse maintenance and function, the objectiv...

journal_title：Journal of psychiatric research

authors： Freemantle E,Mechawar N,Turecki G

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Chronic users of cannabis often report withdrawal symptoms after abstinence from use, but little is known about cannabis withdrawal in people with schizophrenia. METHODS:Cannabis use patterns and withdrawal symptoms in adults with schizophrenia who had at least weekly cannabis use before attempting to quit ...

journal_title：Journal of psychiatric research

authors： Boggs DL,Kelly DL,Liu F,Linthicum JA,Turner H,Schroeder JR,McMahon RP,Gorelick DA

更新日期：2013-02-01 00:00:00

abstract：:Diagnosing major depressive disorder (MDD) continues to be based on meeting phenomenological and descriptive criteria. As of yet, there is still no non-invasive, peripheral biomarker that would allow for a certain diagnosis of MDD. The objective of this paper is to use the receiver operating characteristic (ROC) analy...

journal_title：Journal of psychiatric research

authors： Karlović D,Serretti A,Jevtović S,Vrkić N,Serić V,Peleš AM

更新日期：2013-02-01 00:00:00

abstract：:It is generally accepted that patients with major depressive disorder have smaller hippocampus size compared to healthy people. However, it is still not known if this situation exists before the onset of the disease or is a result of the toxic mechanism created by the depression itself. The findings of the long-term f...

journal_title：Journal of psychiatric research

authors： Isıklı S,Ugurlu O,Durmusoglu E,Kizilates G,Kitis O,Ozan E,Eker C,Coburn K,Gonul AS

更新日期：2013-01-01 00:00:00

abstract：:Current standards for treating major depressive disorder (MDD) recommend that achieving remission should be considered the principal goal of treatment. Recent research suggests that the symptom-based definitions of remission used in efficacy studies do not adequately reflect the perspective of depressed patients recei...

journal_title：Journal of psychiatric research

authors： Zimmerman M,Martinez JH,Attiullah N,Friedman M,Toba C,Boerescu DA,Ragheb M

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Clinical and sociodemographic findings have supported that OCD is heterogeneous and composed of multiple potentially overlapping and stable symptom dimensions. Previous neuroimaging investigations have correlated different patterns of OCD dimension scores and gray matter (GM) volumes. Despite their relevant ...

journal_title：Journal of psychiatric research

authors： Alvarenga PG,do Rosário MC,Batistuzzo MC,Diniz JB,Shavitt RG,Duran FL,Dougherty DD,Bressan RA,Miguel EC,Hoexter MQ

更新日期：2012-12-01 00:00:00

abstract：:Psychopathological symptoms in patients with primary aldosteronism (PA) have been reported. In a cross-sectional design the self-reported physical and mental condition among patients with PA of the German Conn's Registry differently treated during the course of the disease were analysed. 27 patients were investigated ...

journal_title：Journal of psychiatric research

authors： Künzel HE,Apostolopoulou K,Pallauf A,Gerum S,Merkle K,Schulz S,Fischer E,Brand V,Bidlingmaier M,Endres S,Beuschlein F,Reincke M

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVE:To determine whether the combination of triiodothyronine (T3) plus sertraline at treatment initiation confers greater antidepressant efficacy than sertraline plus placebo in patients with major depressive disorder. METHOD:Eight-week, double blind, randomized placebo controlled clinical trial of 153 adult out...

journal_title：Journal of psychiatric research

authors： Garlow SJ,Dunlop BW,Ninan PT,Nemeroff CB

更新日期：2012-11-01 00:00:00